Debt Securities, Available-for-Sale [Abstract]
2024
Lessee, Operating Lease, Liability, to be Paid, Year One
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Document Transition Report
Document Transition Report
uniQure
Uni Qure Biopharma B V [Member]
uniQure biopharma B.V.
Revenue, Remaining Performance Obligation, Amount
Aggregate amount of transaction price allocated to remaining performance obligation
Remaining performance obligations
Money Market Funds
Money Market Funds [Member]
Contingent payments development milestones.
Contingent payments development milestones
Contingent payments development milestones
Payments of Stock Issuance Costs
Payment of offering costs
ATM offering costs
Issuance of Common Stock upon Exercise of Stock Options and Warrants
Issuance of common stock upon exercise of stock options and warrants.
Issuance of common stock upon exercise of stock options and warrants
Geographical
Geographical [Axis]
Summary of Changes in Fair Value of Level 3 Financial Instruments
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Debt Securities, Available-for-Sale
Debt Securities, Available-for-sale, Total
Fair Value
Total other liabilities, noncurrent
Other liabilities
Other Liabilities, Noncurrent
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
License Arrangements
License Arrangements [Text Block]
License arrangements.
Level 1
Fair Value, Inputs, Level 1 [Member]
Other impairment charges related to marketable securities
Other Impairment Charge Related To Marketable Securities
Other impairment charge related to marketable securities.
2027
Lessee, Operating Lease, Liability, to be Paid, Year Four
Additional funding upon acceptance of investigational New Drug application
Additional funding committed.
Additional Funding Committed
Fair Value Measurements
Fair Value Disclosures [Text Block]
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Collaboration and license revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Lessee, Operating Lease, Disclosure [Table Text Block]
Summary of Supplemental Information Related to Leases
Disaggregation of Revenue [Table Text Block]
Summary of Collaboration and License Revenue
Concentration Risk Type
Concentration Risk Type [Axis]
Assets, Transfers into Level 3
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3
Number of installments to pay actual award
Number Of Installments To Pay Actual Award
Number of installments to pay actual award.
Deferred revenue
Contract with Customer, Liability, Current
Aggregate fair value of securities held in a continuous unrealized loss position for less than twelve months
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
UC Regents and the Trustees of the University of Pennsylvania
U C Regents and the Trustees of the University of Pennsylvania [Member]
U C Regents and the Trustees of the University of Pennsylvania [Member]
Collaborative arrangement receive future option fees and milestones
Collaborative Arrangement Receive Future Option Fees and Milestones
Future option fees and milestones
Lease incentive liability
Lease Incentive Liability
Lease incentive liability.
Amount paid non-refundable license fee
Amounts Paid Non Refundable License Fees
Amount paid non-refundable license fees.
Netherlands
NETHERLANDS
Amended uniQure Agreement and Second uniQure Agreement
Amended UniQure Agreement and Second UniQure Agreement [Member]
Amended uniQure agreement and second uniQure agreement.
Fair Value Hierarchy for Financial Assets and Financial Liabilities Measured at Fair Value on Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Operating lease liabilities, long-term portion
Operating Lease, Liability, Noncurrent
Schedule Of Stock By Class [Table]
Schedule of Stock by Class [Table]
Debt Securities, Available-for-Sale [Table]
Class Of Stock [Line Items]
Class of Stock [Line Items]
Related Party Transactions [Abstract]
Balance Sheet Location [Axis]
Total current assets
Assets, Current
Total liabilities and stockholders’ equity
Liabilities and Equity
Entity Address, State or Province
Entity Address, State or Province
Derivative Liability
Derivative Instruments and Hedging Activities Disclosure [Text Block]
Stock Issued During Period, Value, New Issues
Issuance of common stock for the offering program, net of issuance costs
Number of Shares Underlying Outstanding Options, Balances at December 31, 2022
Number of options outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of Shares Underlying Outstanding Options, Balances at June 30, 2023
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Total Comprehensive loss
Trading Symbol
Trading Symbol
Non-refundable license fee payable upon execution
Non Refundable License Fee Payable Upon Execution
Non-refundable license fee payable upon execution.
Number of additional shares available for grant
Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Available For Grant
Share based compensation arrangement by share based payment award number of additional shares available for grant.
Aggregate fair value of marketable securities in unrealized gain position
Aggregate fair value of marketable securities in unrealized gain position
Aggregate fair value of marketable securities in unrealized gain position.
Common Stock, Shares, Issued, Total
Common stock, shares, issued
Common Stock, Shares, Issued
Debt Securities, Available-for-Sale [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Contract with Customer, Receivable, after Allowance for Credit Loss, Total
Accounts receivable
Contract with Customer, Receivable, after Allowance for Credit Loss
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Lease extended term date
Lease Expiration Date
Shares, Outstanding
Stockholders' Equity, beginning balances (in shares)
Stockholders' Equity, ending balances (in shares)
2026
Lessee, Operating Lease, Liability, to be Paid, Year Three
Number of shares reserved for issuance
Common stock reserved
Common Stock, Capital Shares Reserved for Future Issuance
Issuance of common stock - 2020 ESPP
Proceeds From Issuance of Employee Stock Plans
Proceeds from issuance of employee stock plans.
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Gain (Loss)
Number of sponsored research agreements entered
Number Of Agreements Entered
Number of agreements entered.
Percentage of equity interests issued as common stock
Percentage Of Equity Interests Issued As Common Stock
Percentage of equity interests issued as common stock.
Schedule of common share reserved for future issuance.
Schedule Of Common Share Reserved For Future Issuance [Table Text Block]
Schedule of Common Share Reserved for Future Issuance
Entity Address, City or Town
Entity Address, City or Town
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Lease renewal term
Lessee, Operating Lease, Renewal Term
Schedule of Property and Equipment, Net
Property, Plant and Equipment [Table Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Number of Shares Underlying Outstanding Options, expired
Number of Shares Underlying Outstanding Options, expired
Subsequent Events
Subsequent Event [Member]
Subsequent Event Type [Axis]
Accrued clinical and preclinical study costs
Accrued Clinical And Preclinical Study Costs
Accrued clinical and preclinical study costs.
Unpaid offering costs.
Unpaid Offering Costs
Unpaid offering costs
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Current liabilities
Liabilities, Current [Abstract]
Aggregate fair value of marketable securities in a continuous loss position for more than twelve months
Individual securities held in an unrealized loss position for 12 months or greater
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Current assets:
Assets, Current [Abstract]
Counterparty Name
Counterparty Name [Axis]
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
Summary of Accrued and Other Current Liabilities
Schedule Of Accrued And Other Current Liabilities [Table Text Block]
Schedule of accrued and other current liabilities.
Employee stock purchase plan shares expected to be issued.
Employee Stock Purchase Plan Shares Expected To Be Issued [Member]
ESPP Shares Expected to be Issued
Statement of Stockholders' Equity [Abstract]
Change in accounting principle accounting standards update, immaterial effect
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in fair value of derivative liability
Increase (Decrease) in Derivative Liabilities
Operating lease liabilities, current portion
Operating Lease, Liability, Current
Less: Current portion of operating lease liabilities
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Summary of significant accounting policies line items.
UC Agreements
U C Agreements [Member]
UC Agreements.
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Class of Stock [Domain]
Non-refundable license fee payable annually
Amount Obligated To Pay Non Refundable License Fee Annually
Amount obligated to pay a non-refundable license fee annually.
Investment Income, Interest
Interest income
Statement of Comprehensive Income [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Expected payments multiples to equal actual award received
Future Sales Based Milestone Payment Expected Payments Multiples of Actual Award Received
Future sales based milestone payment expected payments multiples of actual award received.
Entity Central Index Key
Entity Central Index Key
Warrant shares become exercisable
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrants shares exercised
Plan Name
Plan Name [Domain]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change in accounting principle accounting standards update, adopted
Assets, Fair Value Disclosure, Total
Assets
Assets, Fair Value Disclosure
Share Based Compensation Arrangement by Share Based Payment Award Shares Available for Grant Expirations In Period
Share Based Compensation Arrangement by Share Based Payment Award Shares Available for Grant Expirations In Period
Number of Shares Available for Grant, Options expired
Lease option to renew term description
Lessee, Operating Lease, Option to Extend
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Contingent payments eliminated
Contingent Payments Eliminated
Contingent payments eliminated.
Deferred revenue, estimated performance period
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period
Deferred revenue expected to be recognized over period
Warrant expiration year
Warrant Expires Year
Warrant expires year.
Total current liabilities
Liabilities, Current
Entity Tax Identification Number
Entity Tax Identification Number
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Changes in operating assets and liabilities
Increase (Decrease) in Operating Capital [Abstract]
Corporate bond.
Corporate Bond [Member]
Corporate Bonds
Financial Instruments [Domain]
Liability contingent consideration for future milestone and royalty payments.
Liability Contingent Consideration For Future Milestone And Royalty Payments
Contingent consideration for future milestone and royalty payments
Construction in Progress
Construction in Progress [Member]
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock - 2020 ESPP
Award Type
Award Type [Axis]
Class Of Warrant Or Right [Line Items]
Class of Warrant or Right [Line Items]
Plan Name
Plan Name [Axis]
Upfront consideration payment.
Upfront Consideration Payment
Upfront consideration payment
Geographical
Geographical [Domain]
Lease initial term
Lessee, Operating Lease, Term of Contract
Total assets
Assets
UNITED STATES
US
United States
Operating lease, right-of-use assets
Operating lease right-of-use assets, net
Operating lease right-of-use ("ROU") assets
Retirement Plan Name
Retirement Plan Name [Domain]
Entity Registrant Name
Entity Registrant Name
Liabilities, Transfers out of Level 3
Fair Value, Measurement with Unobservable Inputs Reconciliation, Liability, Transfers out of Level 3
Astellas gene therapies inc
Astellas Gene Therapies INC [Member]
Astellas GeneTherapies Inc
Lease existence of option to renew term
Lessee, Operating Lease, Existence of Option to Extend [true false]
Related Party
Related Party, Type [Domain]
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Machine Learning SRA
Machine Learning Sponsored Research Agreement [Member]
Collaborative arrangement, initial research term
Collaborative Arrangement Initial Research Term
Collaborative arrangement, initial research term.
Accumulated Deficit
Retained Earnings [Member]
Ordinary shares vesting period
Vesting Period Of Share Awards
Vesting period of share awards.
Class of Stock [Axis]
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of common stock - 2020 ESPP (in shares)
Minimum
Minimum [Member]
Minimum [Member]
Total revenue
Revenues
Total revenue
Revenues
Future sales-based milestone payments multiples
Collaborative Arrangements Future Sales Based Milestone Payments Multiples
Collaborative arrangements future sales based milestone payments multiples.
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Operating Lease, Liability
Present value of future minimum lease payments
Operating lease liability
Present value of future minimum lease payments
Additional investment in cash
Additional investment in cash.
Additional Investment in Cash
Revenue Recognition
Revenue [Policy Text Block]
Expected volatility, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
U.S. Government Sponsored Agencies
US Government Agencies Debt Securities [Member]
Equity Component
Equity Component [Domain]
Long-term marketable securities.
Long-term Marketable Securities [Member]
Long-term Marketable Securities
Options Issued and Outstanding
Employee Stock Option [Member]
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change in accounting principle accounting standards update, adoption date
2015 Equity Incentive Plan
Two Thousand Fifteen Equity Incentive Plan [Member]
Two thousand fifteen equity incentive plan.
Employer contribution
Defined Benefit Plan, Plan Assets, Contributions by Employer
Adjustments to reconcile net loss to net cash used in operating activities
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Measurement Frequency
Measurement Frequency [Axis]
Entity Current Reporting Status
Entity Current Reporting Status
Incurred expenses
Incurred Expenses
Incurred expenses
Common stock, shares authorized
Common Stock, Shares Authorized
Duration of purchase period
Share Based Compensation Arrangement By Share Based Payment Award Duration Purchase Period
Share based compensation arrangement by share based payment award duration purchase period.
Assets
Assets [Abstract]
Aggregate net proceeds, after deducting underwriting discounts and commissions and offering costs
Proceeds from Issuance of Common Stock
Issuance of common stock upon public offering, net of issuance costs
Issuance of common stock for the offering program, net of issuance costs
Number of Shares Available for Grant, Balances at December 31, 2022
Number of shares available for grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Number of Shares Available for Grant, Balances at June 30, 2023
Organization And Nature Of Business [Table]
Organization And Nature Of Business [Table]
Organization and nature of business.
Accrued interest receivable
Interest Receivable, Current
Common stock, $0.0001 par value, 300,000,000 shares authorized at September 30, 2023 and December 31, 2022; 42,752,452 and 32,626,627 shares issued and outstanding at September 30, 2023 and December 31, 2022, respectively
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
Revenue included in deferred revenue at the beginning of the current year
Contract with Customer, Liability, Revenue Recognized
Revenue recognized
Furniture and Fixtures
Furniture and Fixtures [Member]
Accrued Liabilities, Current
Accrued and other current liabilities
Total accrued and other current liabilities
Deferred rent
Deferred Rent Credit
Current Fiscal Year End Date
Current Fiscal Year End Date
uniQure Agreement
Uni Qure Agreement [Member]
uniQure Agreement.
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Loss from operations
Operating Income (Loss)
Realized gains or losses on marketable securities
Debt Securities, Available-for-Sale, Realized Gain (Loss)
Debt Securities, Available-for-Sale, Realized Gain (Loss), Total
Astellas
Astellas [Member]
Astellas.
Entity Ex Transition Period
Entity Ex Transition Period
Asset Acquisition, Contingent Consideration, Liability, Total
Asset Acquisition, Contingent Consideration, Liability
Liability related to contingent consideration
Research and Development
Research and Development Expense [Member]
Lessee, Leases [Policy Text Block]
Leases
Concentration risk, percentage
Concentration Risk, Percentage
Increase in shares available for issuance percentage
Increase in Shares Available for Issuance Percentage
Increase in shares available for issuance percentage.
Share-Based Payment Arrangement, Expense
Total stock-based compensation expense
Expected volatility, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Offering costs.
Offering Costs [Member]
Offering Costs
Disaggregation Of Revenue [Table]
Disaggregation of Revenue [Table]
UC Regents
U C Regents [Member]
UC Regents.
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities
Concentration Risk [Line Items]
Concentration Risk [Line Items]
Percentage of common stock outstanding increased annually for future issuance
Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Outstanding Stock Increased Annually For Future Issuance
Share based compensation arrangement by share based payment award percentage of outstanding stock increased annually for future issuance.
Accounting Standards Update 2016-02
Accounting Standards Update 2016-02 [Member]
Deferred Revenue, Total
Deferred revenue
Deferred Revenue
Collaborative arrangements special term
Collaborative Arrangements Special Term
Collaborative arrangements special term.
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Earnings Per Share, Policy [Policy Text Block]
Net Loss Per Share, Basic and Diluted
Liabilities, Level 1 and Level 2 transfers
Fair Value Liabilities Level One And Level Two Transfers Amount
Fair value liabilities level one and level two transfers amount.
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other income (expense), net
Change in fair value included in other income (expense), net
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Operating expenses:
Operating Expenses [Abstract]
Property, Plant and Equipment [Abstract]
CRF Agreement
Choroideremia Research Foundation Agreement [Member]
Choroideremia Research Foundation Agreement.
Schedule of Revenues by Geographic Region
Revenue from External Customers by Geographic Areas [Table Text Block]
Increase (decrease) in revenue recognized
Increase Decrease In Contract With Customer Revenue Recognized
Increase (decrease) in revenue recognized related to performance obligations partially satisfied in the beginning of the current year.
Increase in revenue recognized related to performance obligations partially satisfied in the beginning of the current year
Depreciation, Depletion and Amortization, Nonproduction, Total
Depreciation and amortization
Depreciation, Depletion and Amortization, Nonproduction
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive loss:
Debt Securities, Available-for-Sale [Table Text Block]
Summary of Available for Sale Securities
Fair value of non monetary consideration of intellectual property right
Fair Value Of Non Monetary Consideration Of Intellectual Property Right
Fair value of non monetary consideration of intellectual property right.
Commitments and Contingencies Disclosure [Abstract]
Other Assets, Noncurrent, Total
Other assets
Other Assets, Noncurrent
Number of Shares Underlying Outstanding Options, granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Other accrued expenses
Other Accrued Liabilities, Current
Common Stock
Equity [Text Block]
Depreciation, Total
Depreciation expense
Depreciation
Warrant exercised month and year
Warrant Exercised Month And Year
Warrant exercised month and year.
Summary of Deferred Revenue
Deferred Revenue, by Arrangement, Disclosure [Table Text Block]
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Gains
Derivative [Line Items]
Derivative [Line Items]
Contingent payments development milestones for initial target.
Contingent Payments Development Milestones for Initial Target
Contingent payments development milestones initial target
Stockholders’ equity
Equity, Attributable to Parent [Abstract]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Lease, Cost [Table Text Block]
Summary of Components of Lease Expense
CFF
Cystic Fibrosis Foundation [Member]
Cystic Fibrosis Foundation [Member]
Lease initial term
Lessor, Operating Lease, Term of Contract
Lease Contractual Term [Domain]
Earnings Per Share [Abstract]
Summary of Future Minimum Commitments Under Lease Contracts
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Upfront payments received
Collaboration Arrangements Upfront Payment Received
Collaboration arrangements upfront payment received.
Dividends, Common Stock, Total
Common stock dividend
Dividends, Common Stock
Accounting Policies [Abstract]
Deferred ATM costs reclassification
Deferred ATM Costs Reclassification
Deferred ATM costs reclassification
Liability Class
Liability Class [Axis]
Concentration of Credit Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Investment in redeemable convertible preferred stock financing
Sale of Stock, Consideration Received on Transaction
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Net loss per share, basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Customer Concentration Risk
Customer Concentration Risk [Member]
Warrant vesting period
Warrant Vesting Period
Warrant vesting period.
Commitments and Contingencies
Commitments and contingencies (Note 9)
License agreement with university of Pennsylvania.
License Agreement With University Of Pennsylvania [Member]
License Agreement for sCFH with University of Pennsylvania
Maturity period of marketable securities
Debt Securities, Available-for-Sale, Term
Contingent payments entitled to receive for achievement of research and development milestones
Collaborative Arrangement Research And Development Milestones Entitled To Receive For Each Licensed Product
Collaborative arrangement research and development milestones entitled to receive for each licensed product.
Income Statement [Abstract]
Property and Equipment, Net
Property, Plant and Equipment Disclosure [Text Block]
Related Party
Related Party, Type [Axis]
Operating Lease, Cost
Operating Lease, Cost
Operating lease cost
Retirement Benefits [Abstract]
Number of Shares Underlying Outstanding Options, Options vested and expected to vest at March 31, 2023
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Statistical Measurement
Statistical Measurement [Domain]
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Award Type
All Award Types
Document Period End Date
Document Period End Date
Statistical Measurement
Statistical Measurement [Axis]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Net loss per share, diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Product and Service
Product and Service [Domain]
Concentration Risk Benchmark
Concentration Risk Benchmark [Domain]
Number of warrant shares issued
Number Of Warrant Shares Issued
Number of warrant shares issued.
Credit Concentration Risk
Credit Concentration Risk [Member]
Aggregate unrealized loss
Aggregate Unrealized Loss
Aggregate unrealized loss.
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Number of Shares Underlying Outstanding Options, Options exercisable at March 31, 2023
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Derivative liability
Derivative Liability, Noncurrent
Related Party Transaction
Related Party Transaction [Domain]
Fair Value on Recurring Basis
Fair Value, Recurring [Member]
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock, Beginning Balance
Additional paid-in-capital
Additional Paid in Capital, Common Stock
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan Disclosure [Line Items]
Payment to related party
Amount Paid to Related Party
Amount paid to related party.
US Treasury Securities [Member]
US Treasuries
Organization And Nature Of Business [Line Items]
Organization And Nature Of Business [Line Items]
Organization and nature of business.
Percentage of equity interest upon closing of first qualified financing at option.
Percentage of equity interest upon closing of first qualified financing at option
Percentage of equity interest upon closing of first qualified financing at option of UC Regents
Customer A
Customer A [Member]
Customer A.
Number of Shares Underlying Outstanding Options, exercised
Issuance of common stock upon exercise of stock options (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Liabilities and Stockholders’ Equity
Liabilities and Equity [Abstract]
Numerator
Earnings Per Share Reconciliation [Abstract]
Two Thousand Fourteen Plan [Member]
Two thousand fourteen plan.
2014 401(k) Plan
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Entity Interactive Data Current
Entity Interactive Data Current
Private Placement
Private Placement [Member]
Over-Allotment Option [Member]
Excess of Overallotment Option
Increase (Decrease) in Accounts Payable, Total
Accounts payable
Increase (Decrease) in Accounts Payable
Summary of Aggregate Fair Values of Marketable Securities with Unrealized Losses and Gains
Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block]
Equity [Abstract]
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: Amount representing interest
Less: Amount representing interest
Common stock overlapping offering period
Share Based Compensation Arrangement By Share Based Payment Award Stock Overlapping Offering Period
Share based compensation arrangement by share based payment award stock overlapping offering period.
Allowance for credit loss
Debt Securities, Available-for-Sale, Allowance for Credit Loss
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Ending Balance
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Beginning Balance
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Total
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Cash and Cash Equivalents
Cash and Cash Equivalents, Policy [Policy Text Block]
Equity Components
Equity Components [Axis]
Accounts receivable
Increase (Decrease) in Accounts Receivable
Investments, Debt and Equity Securities [Abstract]
Financial Liabilities Fair Value Disclosure, Total
Liabilities
Financial Liabilities Fair Value Disclosure
Office Equipment
Office Equipment [Member]
Other Risks and Uncertainties
Other Risks And Uncertainties Policy Policy [Text Block]
Other risks and uncertainties.
Local Phone Number
Local Phone Number
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Sale of Stock
Sale of Stock [Axis]
Royalties multiples on actual award received
Collaborative Arrangements Royalties Multiples On Actual Award Received
Collaborative arrangements royalties multiples on actual award received.
Defined Contribution Plan [Table]
Defined Contribution Plan [Table]
Share based compensation arrangement by share based payment award number of duration purchase period.
Share Based Compensation Arrangement By Share Based Payment Award Number Of Duration Purchase Period
Number of duration purchase period
2020 Equity Incentive Award Plan
Two Thousand Twenty Equity Incentive Award Plan [Member]
Two thousand twenty equity incentive award plan.
Statement of Cash Flows [Abstract]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Customer C
Customer C [Member]
Customer C
Vesting of common stock warrant in return for services
Vesting Of Common Stock Warrant In Return For Services
Vesting of common stock warrant in return for services.
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated other comprehensive gain (loss)
Concentration Risk Benchmark
Concentration Risk Benchmark [Axis]
Common stock, par value
Common Stock, Par or Stated Value Per Share
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Number of shares authorized
Number of shares authorized and reserved for issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Research and Collaboration Arrangements
Collaborative Arrangement Disclosure [Text Block]
Maximum
Maximum [Member]
Continuous period where the Company ceases to develop or commercialize any product
Continuous Period Where Company Ceases To Develop Or Commercialize Any Product
Continuous period where the Company ceases to develop or commercialize any product.
Retirement Plan Name
Retirement Plan Name [Axis]
Proceeds from offering of securities in a private placement
Proceeds from Issuance of Private Placement
Vesting of common stock warrants
Adjustments To Additional Paid In Capital Vesting Of Stock Warrant Issued For Services
Adjustments to additional paid in capital vesting of stock warrant issued for services.
Vesting of common stock warrants issued for services
Temporary Equity, Shares Outstanding
Outstanding shares of redeemable convertible preferred stock
Redeemable Convertible Preferred Stock, beginning balances (in shares)
Redeemable Convertible Preferred Stock, ending balances (in shares)
Related Party Transaction
Related Party Transaction [Axis]
The Company
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Warrant shares, expense recognized
Class Of Warrant Expense
Class of warrant expense.
Level 3
Fair Value, Inputs, Level 3 [Member]
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation expense
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Net increase (decrease) in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Liabilities, Transfers into Level 3
Fair Value, Measurement with Unobservable Inputs Reconciliation, Liability, Transfers Into Level 3
Payables and Accruals [Abstract]
General and Administrative
General and Administrative Expense [Member]
Common Stock Warrants
Common Stock Warrants [Text Block]
Common stock warrants.
Number of Shares Underlying Outstanding Options, forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Outstanding Shares of Potentially Dilutive Securities Excluded from Computation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
City Area Code
City Area Code
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Cash flows from operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Exercise price as percentage of fair market value, minimum
Share Based Compensation Arrangement By Share Based Payment Award Exercise Price As Percentage Of Fair Market Value Minimum
Share based compensation arrangement by share based payment award exercise price as percentage of fair market value minimum.
401(K) Plan
Defined Contribution Plan [Text Block]
Common stock voting rights
Common Stock, Voting Rights
Customer
Customer [Domain]
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Less: Accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
General and Administrative Expense, Total
General and administrative
General and Administrative Expense
Weighted-average shares outstanding used in computing net loss per share, basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Assets, Level 1 and Level 2 transfers
Fair Value Assets Level One And Level Two Transfers Amount
Fair value assets level one and level two transfers amount.
Research and Development Arrangement, Contract to Perform for Others, Type
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Cash flows from financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Estimate of expected credit loss
Debt Securities, Held-to-Maturity, Credit Loss Expense (Reversal)
Statement [Table]
Statement [Table]
Summary of Stock Options Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Accounts Receivable
Accounts Receivable [Member]
Schedule Of Related Party Transactions By Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Assumptions Used in Black-Scholes Valuation Model to Estimate Fair Value of Stock Options
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Document Fiscal Period Focus
Document Fiscal Period Focus
Lessee, Operating Lease, Liability, to be Paid
Total future minimum lease payments
Fair value of options
Fair Value Of Options
Fair value of options.
Warrant shares, exercised
Number Of Warrant Shares Exercised
Number of warrant shares exercised.
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
2025
Lessee, Operating Lease, Liability, to be Paid, Year Two
Consulting and professional
Accrued Professional Fees, Current
Research and development (includes $0 for each of the three months ended September 30, 2023 and 2022, respectively, and $0 and $134 for the nine months ended September 30, 2023 and 2022, respectively, attributable to related parties)
Research and Development Expense (Excluding Acquired in Process Cost)
Statement [Line Items]
Statement [Line Items]
Collaboration and License Revenue
Collaboration And License Revenue [Member]
Collaboration and License Revenue.
Future sales-based milestone payments multiples
Collaborative Arrangements Future Sales Based Milestone Payment Multiples
Collaborative arrangements future sales based milestone payment multiples.
Number of Shares Available for Grant, Options granted
Share Based Compensation Arrangement By Share Based Payment Award Shares Available For Grant Grants In Period Gross
Share based compensation arrangement by share based payment award shares available for grant grants in period gross.
Other impairment charges related to marketable securities
Other Impairment Charges Related to Marketable Securities
Other impairment charges related to marketable securities.
Antidilutive securities
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Beginning Balance
Ending Balance
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Minimum percentage of outstanding shares held by individual
Minimum Percentage Of Outstanding Shares Held By Individual
Minimum percentage of outstanding shares held by individual
Machinery and Equipment
Machinery and Equipment [Member]
Lease, Cost, Total
Lease, Cost
Total
Common Stock Warrants
Warrant [Member]
Collaborative arrangement achieved milestones
Collaborative Arrangement Achieved Milestones
Collaborative arrangement achieved milestones.
Asset Class
Asset Class [Domain]
Net unrealized gain (loss) on marketable securities
Stock issued during period value net unrealized gain (loss) on sale of marketable securities.
Stock Issued During Period Value Net Unrealized Gain (Loss) on Sale of Marketable Securities
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current
Customer
Customer [Axis]
Embedded Derivative
Derivatives, Policy [Policy Text Block]
Common Stock
Common Stock [Member]
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock-based Compensation Expense for Employees and Nonemployees by Function
Accretion (Amortization) of Discounts and Premiums, Investments
Net amortization (accretion) of premium (discount) on marketable securities
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Accounts payable, related party
Accounts Payable
Accounts Payable, Total
2021 Follow On Public Offering
Two thousand Twenty One Follow On Public Offering [Member]
Two thousand twenty one follow on public offering
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Accounting Standards Update 2016-13
Accounting Standards Update 2016-13 [Member]
CFF Agreement
Cystic Fibrosis Foundation Agreement [Member]
Cystic Fibrosis Foundation Agreement.
Cover [Abstract]
Collaborative arrangement additional research term
Collaborative Arrangement Additional Research Term
Collaborative arrangement additional research term.
Document Fiscal Year Focus
Document Fiscal Year Focus
Assets, Transfers out of Level 3
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers out of Level 3
Series B financing.
Series B Financing [Member]
Series B Financing
Schedule of common shares reserved for future issuance [Table Text Block]
Schedule Of Common Shares Reserved For Future Issuance [Table Text Block]
Schedule of Common Shares Reserved for Future Issuance
Expected payments multiples to equal actual award received
Future Sales Based Milestone Payments Expected Payments Multiples Of Actual Award Received
Future sales based milestone payments expected payments multiples of actual award received.
Sale of Stock
Sale of Stock [Domain]
Research And Collaboration Arrangements [Abstract]
Research and Collaboration Arrangements.
Number of Shares Available for Grant, Options forfeited
Share Based Compensation Arrangement By Share Based Payment Award Shares Available For Grant Forfeitures In Period
Share based compensation arrangement by share based payment award shares available for grant forfeitures in period.
2023 Follow On Public Offering
Two Thousand Twenty Three Follow On Public Offering [Member]
Two thousand twenty three follow on public offering.
Security Exchange Name
Security Exchange Name
Options exercisable period
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Recently Adopted Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Preferred stock, shares issued
Preferred Stock, Shares Issued
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Related party expenses
Operating Costs and Expenses
Operating Costs and Expenses, Total
SRAs
Sponsored Research Agreements [Member]
Sponsored Research Agreements.
Estimated fair value of derivative liability
Derivative Liability, Subject to Master Netting Arrangement, before Offset
Derivative Liability, Fair Value, Gross Liability, Total
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Total property and equipment
Property, Plant and Equipment, Gross
Potential cash payment upon achievement of certain late-stage development, regulatory and sales milestones.
Potential Cash Payment Upon Achievement Of Certain Late Stage Development Regulatory And Sales Milestones
Potential cash payment upon achievement of certain late-stage development, regulatory and sales milestones
Change in control event percentage
Fair Value Assumptions Probability Of Change In Control Event Percentage
Fair value assumptions probability of change in control event percentage.
Financial Instrument [Axis]
Denominator
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Class Of Warrant Or Right [Table]
Class of Warrant or Right [Table]
Issuance of common stock upon exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Entity Emerging Growth Company
Entity Emerging Growth Company
Number shares issued upon conversion of redeemable convertible preferred shares
Convertible Preferred Stock, Shares Issued upon Conversion
Amendment Flag
Amendment Flag
Marketable Securities, Current, Total
Marketable Securities, Current
Marketable securities
Amount obligated to pay upon closing first qualified financing at option of UC Regents
Amount Obligated To Pay Upon Closing First Qualified Financing At Option
Amount obligated to pay upon closing first qualified financing at option.
Initial Public Offering
IPO [Member]
Computation of Basic and Diluted Net Loss Per Share
Schedule of Weighted Average Number of Shares [Table Text Block]
5980 Horton Street Building Lease
Five Nine Eight Zero Horton Street [Member]
5980 Horton Street.
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Gross Unrealized Losses
Accounting Standards Update [Domain]
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
SRAs and Machine Learning SRA
Sponsored Research Agreements And Machine Learning Sponsored Research Agreements [Member]
Number of shares priced under public offering
Shares, Issued
Shares, Issued, Beginning Balance
Shares, Issued, Ending Balance
Class of warrants expense.
Class Of Warrants Expense
Warrant expense recognized
Maximum unrealized loss at individual instrument level
Maximum Unrealized Loss at Individual Instrument Level
Maximum unrealized loss at individual instrument level.
Aevitas therapeutics, Inc. agreement.
Aevitas Therapeutics Inc Agreement [Member]
Aevitas Therapeutics, Inc. Agreement
Commitment And Contingencies [Line Items]
Commitment And Contingencies [Line Items]
Commitment and contingencies.
Entity File Number
Securities Act File Number
Collaborative arrangement transaction price adjustment.
Collaborative Arrangement Transaction Price Adjustment
Collaborative arrangement transaction price adjustment
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Series C Redeemable Convertible Preferred Stock.
Series C Redeemable Convertible Preferred Stock [Member]
Series C Redeemable Convertible Preferred Stock
2023 (remaining three months)
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
Amount due to related party
Other Liabilities
Other Liabilities, Total
Net unrealized gain (loss) on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Due to/from customer
Due to from Customer
Due (to) from Customer.
Share-Based Payment Arrangement [Abstract]
Amended uniQure Agreement
Amended Uni Qure Agreement [Member]
Amended uniQure agreement.
Change of control payment
Fair Value Assumptions Change Of Control Payment
Fair value assumptions change of control payment.
Due to/from customer
Accounts Payable, Current, Total
Accounts Payable, Current
Accounts payable
Total operating expenses
Operating Expenses
Schedule of Concentration of Risk
Schedules of Concentration of Risk, by Risk Factor [Table Text Block]
Expected term
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Preferred stock, $0.0001 par value, 10,000,000 shares authorized at September 30, 2023 and December 31, 2022; no shares issued and outstanding at September 30, 2023 and December 31, 2022
Preferred Stock, Value, Issued
Entity Small Business
Entity Small Business
Entity Shell Company
Entity Shell Company
Investment Type [Axis]
Accrued and Other Current Liabilities
Accrued And Other Current Liabilities [Text Block]
Accrued and other current liabilities.
Exercise price
Class of Warrant or Right, Exercise Price of Warrants or Rights
Class of Warrant or Right
Class of Warrant or Right [Domain]
Computer Equipment and Software
Computer Equipment [Member]
Net Loss Per Share, Basic and Diluted
Earnings Per Share [Text Block]
Change in control discount rate
Fair Value Assumptions Probability Of Change In Control Discount Rate
Fair value assumptions probability of change in control discount rate.
Revenue:
Revenues [Abstract]
Commercial Paper [Member]
Commercial Paper
Entity Address, Address Line One
Entity Address, Address Line One
Revenue
Revenue Benchmark [Member]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Antidilutive Securities
Antidilutive Securities [Axis]
Receivable for common stock issued upon exercise of stock options
Receivable for Common Stock Issued Upon Stock Option Exercises
Receivable for common stock issued upon stock option exercises.
Public Offering.
Public Offering [Member]
Public offering
Subsequent Event Type [Domain]
Actual award payment period upon first commercial sale of product
Actual Award Payment Period Upon First Commercial Sale Of Product
Actual award payment period upon first commercial sale of product.
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
ATM offering costs
ATM offering costs
Risk-free interest rate, minimum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Tenant improvement allowance
Proceeds From Tenant Improvement Allowance
Proceeds from tenant improvement allowance.
Income Statement Location
Income Statement Location [Axis]
Variable Lease, Cost
Variable Lease, Cost
Variable lease cost
Risk-free interest rate, maximum
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
License Arrangements [Abstract]
License arrangements.
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Level 2
Fair Value, Inputs, Level 2 [Member]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Product and Service
Product and Service [Axis]
Deferred revenue, net of current portion
Contract with Customer, Liability, Noncurrent
Title of 12(b) Security
Title of 12(b) Security
Research and development expense, related party
Research And Development Expense Related Party
Research and development expense related party.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Summary of significant accounting policies.
Lease Contractual Term [Axis]
Percentage of maximum contributions of employee's eligible compensation
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Investments [Domain]
Accounting Standards Update [Axis]
Prepaid Expenses and Other Current Assets
Prepaid Expenses and Other Current Assets [Member]
Cash flows from investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Derivative [Table]
Derivative [Table]
Building lease.
Building Lease [Member]
5980 Horton Street Building Lease
Segment Information
Segment Reporting, Policy [Policy Text Block]
Concentration Risk [Table]
Concentration Risk [Table]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Fair Value, Recurring Basis, Unobservable Input Reconciliation, Liability, Gain (Loss), Statement of Income [Extensible List]
Fair Value, Liability, Recurring Basis, Unobservable Input Reconciliation, Gain (Loss), Statement of Income or Comprehensive Income [Extensible Enumeration]
Contract with Customer, Liability, Total
Deferred revenue
Contract with Customer, Liability
Total deferred revenue
Other-than-temporary impairment on investment in debt securities available-for-sale
Other-than-temporary Impairment Loss, Debt Securities, Available-for-Sale, Recognized in Earnings
Short-term marketable securities.
Short-term Marketable Securities [Member]
Short-term Marketable Securities
Increased aggregate milestone payments
Increased Aggregate Milestone Payments
Increased aggregate milestone payments.
Commitment And Contingencies [Table]
Commitment And Contingencies [Table]
Commitment and contingencies.
Agreement terminated month and year.
Agreement Terminated Month and Year
Agreement terminated
ATM offering program.
ATM Offering Program
Atm offering program
ATM Offering Program [Member]
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock, shares, outstanding
Common Stock, Shares, Outstanding
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Stock-based Compensation
Share-Based Payment Arrangement [Text Block]
Customer B
Customer B [Member]
Customer B.
Non-refundable license fee payable upon execution every year thereafter until sales of a licensed product and payment of royalties
Non Refundable License Fee Payable Every Year After Execution
Non-refundable license fee payable every year after execution until sales of a licensed product are made and royalties paid.
Business Combinations Policy [Policy Text Block]
Acquisitions
Derivative Liability
Derivative Financial Instruments, Liabilities [Member]
Concentration Risk Type
Concentration Risk Type [Domain]
Lessee, Operating Lease, Discount Rate
Weighted-average discount rate
Operating lease, discount rate
Income Statement Location
Income Statement Location [Domain]
Common Stock Warrants
Common Stock Warrants Policy Policy [Text Block]
Common stock warrants.
Document Type
Document Type
Fair Value by Liability Class
Fair Value by Liability Class [Domain]
Net Cash Provided by (Used in) Investing Activities
Net cash provided by investing activities
Document Quarterly Report
Document Quarterly Report
Marketable Securities, Noncurrent, Total
Marketable Securities, Noncurrent
Marketable securities, long-term
Marketable Securities
Marketable Securities, Total
Counterparty Name
Counterparty Name [Domain]
Net Income (Loss) Available to Common Stockholders, Basic
Net Income (Loss) Available to Common Stockholders, Basic, Total
Net loss
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Number of Shares Available for Grant, Options authorized
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Entity Filer Category
Entity Filer Category
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental disclosures of noncash investing and financing information
Royalties multiples on actual award received
Collaborative Arrangement Royalties Multiples On Actual Award Received
Collaborative arrangement royalties multiples on actual award received.
Balance Sheet Location [Domain]
Maximum unrealized loss
Maximum Unrealized Loss
Maximum unrealized loss.
Other assets
Other assets
Increase (Decrease) in Other Noncurrent Assets
Increase (Decrease) in Accrued Liabilities, Total
Accrued and other liabilities
Increase (Decrease) in Accrued Liabilities
CRF
Choroideremia Research Foundation [Member]
Choroideremia Research Foundation.
Payments to Acquire Marketable Securities
Payments to Acquire Marketable Securities, Total
Purchase of marketable securities
Purchase of marketable securities
Asset Class
Asset Class [Axis]
Nonoperating Income (Expense)
Total other income (expense), net
Purchases of property and equipment in accounts payable and accrued and other liabilities
Capital Expenditures Incurred but Not yet Paid
Total liabilities
Liabilities
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
5858 Horton Street Building Lease and Expansion
Five Eight Five Eight Horton Street Building Lease and Expansion [Member]
Five eight five eight horton street building lease and expansion.
Total stockholders’ equity
Equity, Attributable to Parent
Stockholders' Equity, beginning balances
Stockholders' Equity, ending balances
Net Income (Loss)
Net loss
Net loss
Other income (expense):
Nonoperating Income (Expense) [Abstract]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Proceeds from tenant improvement allowances.
Proceeds From Tenant Improvement Allowances
Tenant improvement allowances
Corporate Debt Securities [Member]
Corporate Bonds
Fair Value Measurements
Fair Value Measurement, Policy [Policy Text Block]
Collaborative arrangement contribution upon development milestone
Collaborative Arrangement Contribution Upon Development Milestone
Collaborative arrangement contribution upon development milestone.
Statement of Financial Position [Abstract]
Weighted-average shares outstanding used in computing net loss per share, diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Operating Lease, Right-of-Use Asset, Periodic Reduction
Amortization of right-of-use assets
Stock sold and issued price per share
Shares Issued, Price Per Share
Stock issued price per share
Total amount of award under agreement.
Total Amount Of Award Under Agreement
Collaborative arrangement total amount of award
Annual royalty
Annual Royalty
Annual royalty.
Funding Agreement
Funding Agreement [Member]
Funding agreement.
Debt Securities, Available-for-sale, Amortized Cost
Amortized Cost Basis
Options to purchase ordinary shares
Options To Purchase Ordinary Shares
Options to purchase ordinary shares.
Weighted-average remaining lease term (in years)
Operating Lease, Weighted Average Remaining Lease Term
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Employee purchase price of common stock as percentage of fair market value
Use of Estimates and Judgements
Use of Estimates, Policy [Policy Text Block]
Lessee operating lease liability payments due after year four.
Lessee Operating Lease Liability Payments Due After Year Four
Thereafter
Computation of Basic and Diluted Net Loss Per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
2020 Employee Stock Purchase Plan
2020 ESPP
Two Thousand Twenty Employee Stock Purchase Plan [Member]
Two thousand twenty employee stock purchase plan.
Agreement term
Term Of Agreement
Term of agreement.
Disaggregation Of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Leasehold Improvements
Leasehold Improvements [Member]
Lease extended term period
Operating Lease Term Extended Expiration Period
Operating lease term extended expiration period.
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Fair Value Disclosures [Abstract]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Measurement Frequency
Measurement Frequency [Domain]
Payments to Acquire Property, Plant, and Equipment, Total
Acquisition of property and equipment
Payments to Acquire Property, Plant, and Equipment
Issuance of common stock for the ATM offering program, net of issuance costs (in shares)
Number of shares sold and issued
Issuance of common stock for the offering program, net of issuance costs (in shares)
Employee-related Liabilities, Current, Total
Employee-related Liabilities, Current
Payroll and related expenses
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash and cash equivalents, beginning of period
Cash and cash equivalents, end of period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Class of Warrant or Right
Class of Warrant or Right [Axis]
Customer Member
Customer.
Customer
Proceeds from Sale and Maturity of Marketable Securities, Total
Proceeds from Sale and Maturity of Marketable Securities
Maturities of marketable securities