Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Expected volatility, maximum
Impairment, Long-Lived Asset, Held-for-Use, Total
Impairment, Long-Lived Asset, Held-for-Use
Impairments of long-lived assets
Employee.
Employee [Member]
Employee
Lease Expiration Date
Lease extended term date
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Options exercisable period
Segment Reporting, Policy [Policy Text Block]
Segment Information
uniQure biopharma B.V.
Uni Qure Biopharma B V [Member]
uniQure
Fair Value, Measurement with Unobservable Inputs Reconciliation, Liability, Transfers Into Level 3
Liabilities, Transfers into Level 3
Fair Value, Liabilities, Level 1 to Level 2 Transfers, Amount
Liabilities, Level 1 to Level 2 transfers
Operating Loss Carryforwards
Net operating loss carryforwards
Operating Loss Carryforwards, Total
Issuance of common stock upon exercise of stock options and warrants
Issuance of common stock upon exercise of stock options and warrants.
Issuance of Common Stock upon Exercise of Stock Options and Warrants
Shares Authorized
Temporary equity, shares authorized
Preferred stock, authorized
Auditor Location
Deferred Revenue
Deferred revenue
Deferred Revenue, Total
Operating Expenses [Abstract]
Operating expenses:
License arrangements.
License Arrangements [Text Block]
License Arrangements
Asset Class [Domain]
Asset Class
Operating Income (Loss)
Loss from operations
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
Additional funding upon acceptance of investigational New Drug application
Additional funding committed.
Additional Funding Committed
Concentration Risk Type [Domain]
Concentration Risk Type
Entity Emerging Growth Company
Entity Emerging Growth Company
Derivative Liability, Noncurrent
Derivative liability
Income Tax Disclosure [Abstract]
Financial Instrument [Axis]
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Number of Reportable Segments
Number of reportable segments
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Number of Shares Available for Grant, Ending Balance
Number of Shares Available for Grant, Beginning Balance
Number of shares available for grant
Marketable Securities
Marketable Securities, Policy [Policy Text Block]
Payments to Acquire Property, Plant, and Equipment
Acquisition of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Collaborative arrangement adjustment to transaction price.
Collaborative Arrangement Adjustment To Transaction Price
Collaborative arrangement adjustment to transaction price
Geographical [Axis]
Geographical
Common stock, $0.0001 par value, 300,000,000 shares authorized at December 31, 2021 and 2020; 32,224,524 and 26,681,983 shares issued and outstanding at December 31, 2021 and 2020, respectively.
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Entity Address, State or Province
Entity Address, State or Province
Revision of Prior Period, Accounting Standards Update, Adjustment
Revision of Prior Period, Accounting Standards Update, Adjustment [Member]
Liabilities
Total liabilities
Number of installments to pay actual award.
Number Of Installments To Pay Actual Award
Number of installments to pay actual award
Two thousand and seventeen Roche agreement.
Two Thousand And Seventeen Roche Agreement [Member]
2017 Roche Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Risk-free interest rate
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Lease incentive liability
Lease Incentive Liability
Lease incentive liability.
Amount paid non-refundable license fees
Amounts Paid Non Refundable License Fees
Amount paid non-refundable license fees.
Derivative Financial Instruments, Liabilities [Member]
Derivative Liability
Class of Stock [Domain]
Class of Stock
Convertible Preferred Stock, Shares Issued upon Conversion
Shares converted, number of common stock issued
Number shares issued upon conversion of redeemable convertible preferred shares
Gross unrealized loss on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Realized losses on marketable securities
Debt Securities, Available-for-sale, Realized Loss
Weighted-average shares outstanding used in computing net loss per share, basic and diluted
Weighted-average shares outstanding used in computing net loss per share, basic and diluted
Weighted Average Number of Shares Outstanding, Basic and Diluted
Redeemable Convertible Preferred Stock [Member]
Redeemable Convertible Preferred Stock
Accounting Standard Update ("ASU") 2018-18
Accounting Standards Update 2018-18 [Member]
Issuance of common stock upon exercise of stock options and warrants
Stock Issued During Period Value Stock Options And Warrants Exercised
Stock issued during period value stock options and warrants exercised.
Defined Contribution Plan, Employer Discretionary Contribution Amount
Employer contribution
Revenue from Related Parties
Collaboration and license revenue, related parties
Follow-On Offering
Follow on public offering.
Follow On Public Offering [Member]
General and Administrative Expense [Member]
General and Administrative
Weighted-Average Remaining Contractual Term (in years), Shares exercisable, December 31,2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Non-refundable license fee payable upon execution.
Non Refundable License Fee Payable Upon Execution
Non-refundable license fee payable upon execution
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Contract with Customer, Liability, Revenue Recognized
Revenue recognized
Schedule of Related Party Transactions, by Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
City Area Code
City Area Code
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Assumptions Used in Black-Scholes Valuation Model to Estimate Fair Value of Stock Options
Deferred Tax Assets, Gross
Total deferred tax assets
Collaborative arrangements royalties percentage on actual award received.
Collaborative Arrangements Royalties Percentage On Actual Award Received
Royalties percentage on actual award received
Total net deferred tax
Deferred Tax Assets, Net of Valuation Allowance
Net deferred tax assets
US Treasuries
US Treasury Securities [Member]
Revenues [Abstract]
Revenue:
Change in accounting principle accounting standards update, adopted
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Options forfeited
Total deferred revenue
Contract with Customer, Liability
Deferred revenue
Contract with Customer, Liability, Total
Commitments and contingencies (Note 9)
Commitments and Contingencies
Class of Warrant or Right [Line Items]
Class Of Warrant Or Right [Line Items]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Outstanding Shares of Potentially Dilutive Securities Excluded from Computation of Diluted Net Loss Per Share
Number of agreements entered.
Number Of Agreements Entered
Number of sponsored research agreements entered
Percentage of equity interests issued as common stock.
Percentage Of Equity Interests Issued As Common Stock
Percentage of equity interests issued as common stock
Schedule of common share reserved for future issuance.
Schedule Of Common Share Reserved For Future Issuance
Schedule of Common Share Reserved for Future Issuance
Purchase shares of common stock
Issuance of common stock upon initial public offering, net of issuance cost (in shares)
Number of shares sold and issued
Fair Value
Debt Securities, Available-for-sale
Debt Securities, Available-for-sale, Total
Proceeds from Issuance of Convertible Preferred Stock
Issuance of redeemable convertible preferred stock, net of issuance costs
Net proceeds from issuance of convertible preferred stock
Revenue Benchmark [Member]
Revenue
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Accrued clinical and preclinical study costs.
Accrued Clinical And Preclinical Study Costs
Accrued clinical and preclinical study costs
Issuance of common stock - 2020 ESPP (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Unpaid offering costs.
Unpaid Offering Costs
Unpaid offering costs
Related Party [Domain]
Related Party
Change in accounting principle accounting standards update, immaterial effect
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Operating loss carryforwards expiration year.
Operating Loss Carryforwards Expiration Year
Net operating loss carryforwards, expiration year
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Stock Issued During Period, Value, Conversion of Convertible Securities
Conversion of redeemable convertible preferred stock into common stock
Income Statement [Abstract]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Net Cash Provided by (Used in) Investing Activities
Net cash used in investing activities
Capital Expenditures Incurred but Not yet Paid
Purchases of property and equipment in accounts payable and accrued and other liabilities
Summary of significant accounting policies line items.
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
UC Agreements.
U C Agreements [Member]
UC Agreements
Percentage of aggregate number of shares of common stock outstanding reserved for future issuance
Share-based Compensation Arrangement by Share-based Payment Award, Percentage of Outstanding Stock Maximum
Payroll and related expenses
Employee-related Liabilities, Current
Employee-related Liabilities, Current, Total
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Financial Liabilities Fair Value Disclosure
Liabilities
Financial Liabilities Fair Value Disclosure, Total
Property, Plant and Equipment, Net
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Deferred revenue
Contract with Customer, Liability, Current
Amount obligated to pay a non-refundable license fee annually.
Amount Obligated To Pay Non Refundable License Fee Annually
Non-refundable license fee payable annually
Accounts Payable, Related Parties
Accounts payable, related party
Common Stock, Shares, Issued
Common stock, shares, issued
Common Stock, Shares, Issued, Total
Deferred rent
Deferred Rent Credit, Noncurrent
Statement of Comprehensive Income [Abstract]
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
Deferred Tax Liabilities, Gross, Total
Amortized Cost Basis
Debt Securities, Available-for-sale, Amortized Cost
Operating lease, right-of-use assets
Operating lease, right-of-use assets, net
Operating lease right-of-use ("ROU") assets
Customer Concentration Risk [Member]
Customer Concentration Risk
Accounting Standard Update ("ASU") 2018-07
Accounting Standards Update 2018-07 [Member]
Security Exchange Name
Security Exchange Name
Statistical Measurement [Domain]
Statistical Measurement
Share Based Compensation Arrangement by Share Based Payment Award Shares Available for Grant Expirations In Period
Share Based Compensation Arrangement by Share Based Payment Award Shares Available for Grant Expirations In Period
Number of Shares Available for Grant, Options expired
Collaborative arrangement adjustment to transaction price due to increase in project scope and expected reimbursable costs
Collaborative arrangement adjustment to transaction price due to increase in project scope and expected reimbursable costs.
Collaborative Arrangement Increase Of Project Scope And Expected Reimbursable Costs
Furniture and Fixtures [Member]
Furniture and Fixtures
Net Income (Loss) Available to Common Stockholders, Basic
Net loss attributable to common stockholders
Net Income (Loss) Available to Common Stockholders, Basic, Total
Contingent payments eliminated
Contingent Payments Eliminated
Contingent payments eliminated.
Other liabilities
Other Liabilities, Noncurrent
Other liabilities
Total other liabilities, noncurrent
Warrant expires year.
Warrant Expires Year
Warrant expiration year
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers out of Level 3
Assets, Transfers out of Level 3
Accounting Standard Update ("ASU") 2019-12
Accounting Standards Update 2019-12 [Member]
Derivatives, Policy [Policy Text Block]
Embedded Derivative
Credit Concentration Risk [Member]
Credit Concentration Risk
Corporate Bonds
Corporate bond.
Corporate Bond [Member]
Document Period End Date
Document Period End Date
Income Statement Location [Axis]
Income Statement Location
Revision of Prior Period [Domain]
Investments [Domain]
Contingent payment for each nominated product beyond the first three
Collaboration Arrangements Contingent Payment For Each Nominated Product Beyond First Three
Collaboration arrangements contingent payment for each nominated product beyond the first three.
Total accrued and other current liabilities
Accrued and other current liabilities
Accrued and other current liabilities
Accrued Liabilities, Current
Warrant [Member]
Common Stock Warrants
Related Party Transaction, Expenses from Transactions with Related Party
Related party expenses
Related Party Transaction [Axis]
Related Party Transaction
Common Stock, Shares Authorized
Common stock, shares authorized
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Reconciliation of Beginning and Ending Unrecognized Tax Benefits
Use of Estimates, Policy [Policy Text Block]
Use of Estimates and Judgements
Deferred Tax Assets, Deferred Income
Deferred revenue
Fair Value, Liability, Recurring Basis, Unobservable Input Reconciliation, Gain (Loss), Statement of Income or Comprehensive Income [Extensible Enumeration]
Fair Value, Recurring Basis, Unobservable Input Reconciliation, Liability, Gain (Loss), Statement of Income [Extensible List]
Operating lease liabilities, current
Less: Current portion of operating lease liabilities
Operating lease liabilities, current
Operating lease liabilities, current portion
Operating Lease, Liability, Current, Total
Net amortization (accretion) of premium (discount) on marketable securities
Accretion (Amortization) of Discounts and Premiums, Investments
Related Party [Axis]
Related Party
Class of Stock [Axis]
Class of Stock
Research and development (includes $935 and $579 for the years ended December 31, 2021, and 2020, respectively, attributable to related parties)
Research and Development Expense (Excluding Acquired in Process Cost)
Series B redeemable convertible preferred stock.
Series B Redeemable Convertible Preferred Stock [Member]
Series B Redeemable Convertible Preferred Stock
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities
Concentration Risk Benchmark [Domain]
Concentration Risk Benchmark
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities
Machine Learning SRA
Machine Learning Sponsored Research Agreement [Member]
Collaborative arrangement, initial research term.
Collaborative Arrangement Initial Research Term
Collaborative arrangement, initial research term
Vesting period of share awards.
Vesting Period Of Share Awards
Ordinary shares vesting period
Cumulative Effect, Period of Adoption [Axis]
Cumulative Effect, Period of Adoption
Two thousand twenty incentive award plan.
Two Thousand Twenty Incentive Award Plan [Member]
2020 Incentive Award Plan
Stock-based compensation expense
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost
Issuance cost for issuance of preferred stock
Issuance Cost For Issuance Of Preferred Stock
Issuance cost for issuance of preferred stock.
Deferred Tax Liabilities, Net [Abstract]
Effective Income Tax Rate Reconciliation, Percent
Provision for income taxes
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Fair Value Hierarchy for Financial Assets and Financial Liabilities Measured at Fair Value on Recurring Basis
Deferred Tax Assets, Net [Abstract]
Deferred Tax Assets
Machinery and Equipment [Member]
Machinery and Equipment
Current Fiscal Year End Date
Current Fiscal Year End Date
Net (decrease) increase in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Additional investment in cash
Additional investment in cash.
Additional Investment in Cash
Long-term Marketable Securities
Long-term marketable securities.
Long-term Marketable Securities [Member]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period
Deferred revenue, estimated performance period
Operating lease cost
Total operating lease cost
Operating Lease, Cost
2015 Equity Incentive Plan
Two thousand fifteen equity incentive plan.
Two Thousand Fifteen Equity Incentive Plan [Member]
Lessee, Operating Lease, Existence of Option to Extend [true false]
Lease existence of option to renew term
NETHERLANDS
Netherlands
Incurred expenses
Incurred Expenses
Incurred expenses
Disaggregation of Revenue [Table]
Marketable securities, long-term
Marketable Securities, Noncurrent
Marketable Securities, Noncurrent, Total
Counterparty Name [Axis]
Counterparty Name
Assets [Abstract]
Assets
Share based compensation arrangement by share based payment award duration purchase period.
Share Based Compensation Arrangement By Share Based Payment Award Duration Purchase Period
Duration of purchase period
Stock Issued During Period, Shares, Conversion of Convertible Securities
Conversion of redeemable convertible preferred stock into common stock (in shares)
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3
Assets, Transfers into Level 3
Organization and nature of business.
Organization And Nature Of Business [Table]
Organization And Nature Of Business [Table]
2022
Lessee, Operating Lease, Liability, to be Paid, Year One
Fair Value, Assets, Level 2 to Level 1 Transfers, Amount
Assets, Level 2 to Level 1 Transfers
Accounts payable (includes $0 and $173 at December 31, 2021 and 2020, respectively, attributable to related parties)
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Private Placement [Member]
Private Placement
Collaborative arrangement adjustment to transaction price due to variable consideration
Collaborative arrangement adjustment to transaction price due to variable consideration.
Collaborative Arrangement Addition Of Variable Consideration
Common Stock, Par or Stated Value Per Share
Common stock, par value
Defined Contribution Plan [Table]
Defined Contribution Plan [Table]
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Additions for current year tax positions
State and Local Jurisdiction [Member]
State
Shares, Outstanding
Stockholders’ Equity (Deficit), ending balances (in shares)
Stockholders’ Equity (Deficit), beginning balances (in shares)
Investments, Debt and Equity Securities [Abstract]
Additional Paid in Capital, Common Stock
Additional paid-in-capital
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
uniQure Agreement.
Uni Qure Agreement [Member]
uniQure Agreement
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expenses
Fair Value by Liability Class [Domain]
Fair Value by Liability Class
Deferred offering costs.
Deferred Offering Costs Policy Policy [Text Block]
Deferred Offering Costs
Document Type
Document Type
Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Revision of Prior Period [Axis]
Domestic Tax Authority [Member]
Federal
Preferred stock, $0.0001 par value, 10,000,000 shares authorized at December 31, 2021 2020; no shares issued and outstanding at December 31, 2021 and 2020, respectively.
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Derivative [Line Items]
Derivative [Line Items]
Operating lease liabilities, long-term
Operating lease liabilities, long -term portion
Long-term portion of operating lease liabilities
Operating lease liabilities, long-term
Due from Related Parties
Due from related parties
Due from Related Parties, Total
Schedule of Accrued Liabilities [Table Text Block]
Summary of Accrued Liabilities
Assets, Current
Total current assets
Liability Class [Axis]
Liability Class
Disaggregation Of Revenue [Line Items]
UC Regents.
U C Regents [Member]
UC Regents
Percentage of common stock outstanding increased annually for future issuance
Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Outstanding Stock Increased Annually For Future Issuance
Share based compensation arrangement by share based payment award percentage of outstanding stock increased annually for future issuance.
Share-based Payment Arrangement, Option [Member]
Options to Purchase Common Stock
Options Issued and Outstanding
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Contract with Customer, Receivable, after Allowance for Credit Loss
Accounts receivable
Contract with Customer, Receivable, after Allowance for Credit Loss, Total
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Contractual Term (in years), Outstanding
Maturities of marketable securities
Proceeds from Sale and Maturity of Marketable Securities
Proceeds from Sale and Maturity of Marketable Securities, Total
Income tax expense
Income Tax Expense (Benefit)
Income Tax Expense (Benefit), Total
Supplemental disclosures of noncash investing and financing information
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Net loss per share, basic and diluted
Earnings Per Share, Basic and Diluted
Earnings Per Share, Basic and Diluted, Total
Antidilutive Securities [Axis]
Antidilutive Securities
Choroideremia Research Foundation Agreement.
Choroideremia Research Foundation Agreement [Member]
CRF Agreement
Derivative [Table]
Derivative [Table]
Maximum Maturity Period of Marketable Securities
Maximum maturity period of marketable securities
Maximum Maturity Period of Marketable Securities
Increase in revenue recognized related to performance obligations partially satisfied in the beginning of the current year
Increase (decrease) in revenue recognized related to performance obligations partially satisfied in the beginning of the current year.
Increase Decrease In Contract With Customer Revenue Recognized
Aggregate Intrinsic Value, Shares vested and expected to vest, December 31,2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Fair value of non monetary consideration of intellectual property right
Fair Value Of Non Monetary Consideration Of Intellectual Property Right
Fair value of non monetary consideration of intellectual property right.
Receivable for common stock issued upon exercise of stock options
Stock Issued
Common Stock, Shares, Outstanding
Common stock, shares, outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Series A redeemable convertible preferred stock.
Series A Redeemable Convertible Preferred Stock [Member]
Series A Redeemable Convertible Preferred Stock
Class of Warrant or Right [Domain]
Class of Warrant or Right
Plan Name [Axis]
Plan Name
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: Accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Number of Shares Underlying Outstanding Options, forfeited
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Investment in redeemable convertible preferred stock financing
Sale of Stock, Consideration Received on Transaction
Revenue [Policy Text Block]
Revenue Recognition
Warrant exercised month and year
Warrant Exercised Month And Year
Warrant exercised month and year.
Operating Expenses
Total operating expenses
IPO [Member]
Initial Public Offering
Total
Lease, Cost
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator
Financial Instruments [Domain]
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Issuance of common stock upon initial public offering, issuance cost
Gross Unrealized Losses
Gross Unrealized Losses
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted-Average Exercise Price, Ending Balance
Weighted-Average Exercise Price, Beginning Balance
Net Cash Provided by (Used in) Operating Activities [Abstract]
Cash flows from operating activities
Accounting Standards Update [Extensible Enumeration]
Accounting Standards Update [Extensible List]
Cystic Fibrosis Foundation [Member]
Cystic Fibrosis Foundation [Member]
CFF
Summary of Maturities of Lease Liabilities
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise price
Gross Unrealized Gains
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Earnings Per Share [Abstract]
Maximum sales-based milestone payments
Collaborative Arrangement Maximum Sales Based Milestone Payments
Collaborative arrangement maximum sales-based milestone payments.
Upfront payments received
Collaboration Arrangements Upfront Payment Received
Collaboration arrangements upfront payment received.
2023
Lessee, Operating Lease, Liability, to be Paid, Year Two
Net loss
Net Income (Loss) Attributable to Parent
Net loss
Concentration Risk [Line Items]
Concentration Risk [Line Items]
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Effective Tax Rate of Income Tax Expense (Benefit) Differs from Federal Statutory Rate
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk
Research and Development Expense [Member]
Research and Development
Document Fiscal Period Focus
Document Fiscal Period Focus
Temporary Equity, Stock Issued During Period, Value, New Issues
Issuance of redeemable convertible preferred stock, net of $3,138 of issuance cost
Accounting Policies [Abstract]
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Entity Address, Address Line One
Entity Address, Address Line One
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Number of Shares Underlying Outstanding Options, Ending Balance
Number of Shares Underlying Outstanding Options, Beginning Balance
Number of options outstanding
Liabilities, Current
Total current liabilities
Earnings Per Share Reconciliation [Abstract]
Numerator
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Commercial Paper
Commercial Paper [Member]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Title of Individual [Axis]
Title of Individual
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Risk-free interest rate, maximum
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding Balance
Collaborative arrangement research and development milestones entitled to receive for each licensed product.
Collaborative Arrangement Research And Development Milestones Entitled To Receive For Each Licensed Product
Contingent payments entitled to receive for achievement of research and development milestones
Total future minimum lease payments
Lessee, Operating Lease, Liability, to be Paid
Product and Service [Domain]
Product and Service
Temporary Equity, Carrying Amount, Attributable to Parent
Redeemable Convertible Preferred Stock, ending balances
Redeemable Convertible Preferred Stock, beginning balances
Redeemable convertible preferred stock, $0.0001 par value; 0 and 7,375,638 shares authorized shares at December 31, 2020 and 2019, respectively; 0 and 7,375,631 shares issued and outstanding at December 31, 2020 and 2019, respectively. Liquidation value of $0 and $108,596 at December 31, 2020 and 2019, respectively.
Proceeds Net of Issuance Cost
Revenues
Total revenues
Total revenue
Collaboration and license revenue
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized
Number of Shares Available for Grant, Options authorized
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Schedule of Research and Development Arrangement, Contract to Perform for Others [Table]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
5858 Horton Street Building Lease and Expansion
Building Lease and Expansion [Member]
Building lease and expansion.
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Development milestone payments relating to Choroideremia
Collaboration Arrangements Development Milestone Payments Relating To Choroideremia
Collaboration arrangements development milestone payments relating to Choroideremia.
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash and cash equivalents, end of period
Cash and cash equivalents, beginning of period
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Equity Components [Axis]
Equity Components
Summary of Components of Lease Expense
Lease, Cost [Table Text Block]
Assets, Current [Abstract]
Current assets:
Variable lease cost
Variable Lease, Cost
Entity Registrant Name
Entity Registrant Name
Other comprehensive loss:
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Previously Reported
Previously Reported [Member]
Stockholders' Equity Note Disclosure [Text Block]
Common Stock
Realized gains on marketable securities
Debt Securities, Available-for-sale, Realized Gain
Award requisite service period
Share-based Compensation Arrangement by Share-based Payment Award, Award Requisite Service Period
Prepaid expenses to related parties
Prepaid Expenses To Related Parties Current
Prepaid expenses to related parties current.
Entity Interactive Data Current
Entity Interactive Data Current
Entity Address, City or Town
Entity Address, City or Town
Customer [Axis]
Customer
Accounts Receivable [Member]
Accounts Receivable
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Expected volatility, minimum
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Research tax credit
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Expected term
Trading Symbol
Trading Symbol
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Net Cash Provided by (Used in) Investing Activities [Abstract]
Cash flows from investing activities
Less: Amount representing interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Organization and nature of business.
Organization And Nature Of Business [Line Items]
Organization And Nature Of Business [Line Items]
Concentration Risk Type [Axis]
Concentration Risk Type
Percentage of equity interest upon closing of first qualified financing at option of UC Regents
Percentage of equity interest upon closing of first qualified financing at option.
Percentage of equity interest upon closing of first qualified financing at option
Customer A.
Customer A [Member]
Customer A
Accounts Receivable, Allowance for Credit Loss, Current
Allowance for doubtful accounts
Maximum contingent payment upon exercise of the option to convert a product
Collaboration Arrangements Maximum Contingent Payment Upon Exercise Of Option To Convert A Product
Collaboration arrangements maximum contingent payment upon exercise of the option to convert a product.
Local Phone Number
Local Phone Number
ASC 842 Adjustments
Accounting Standard Update ("ASU") 2016-02
Accounting Standards Update 2016-02 [Member]
Total stockholders' equity
Stockholders' Equity Attributable to Parent
Stockholders’ Equity (Deficit), ending balances
Stockholders’ Equity (Deficit), beginning balances
Stockholders' equity attributable to parent
2014 401(k) Plan
Two thousand fourteen plan.
Two Thousand Fourteen Plan [Member]
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Other
Other accrued liabilities
Unrecognized Tax Benefits
Balance at end of year
Balance at beginning of year
Cash paid for amounts included in the measurement of lease liabilities
Operating Lease, Payments
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Issued, Total
Assets, Fair Value Disclosure
Assets
Statistical Measurement [Axis]
Statistical Measurement
Entity Small Business
Entity Small Business
Share based compensation arrangement by share based payment award stock overlapping offering period.
Share Based Compensation Arrangement By Share Based Payment Award Stock Overlapping Offering Period
Common stock overlapping offering period
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Deferred Tax Assets, Tax Credit Carryforwards
Research tax credits
Deferred Tax Assets, Tax Credit Carryforwards, Total
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Leases
Lessee, Leases [Policy Text Block]
Share Price
Original Issuance Price
Temporary equity, shares issued price per share
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Exercise of Overallotment Option
Over-Allotment Option [Member]
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Tax Effects of Temporary Differences to Significant Components of Deferred Taxes
Prepaid expenses
Prepaid expenses
Deferred Tax Liabilities, Prepaid Expenses
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Common Stock, Voting Rights
Common stock voting rights
Property, Plant and Equipment, Useful Life
Property and equipment, estimated useful life
Balance Sheet Location [Axis]
Balance Sheet Location
Fair Value Measurement, Policy [Policy Text Block]
Fair Value Measurements
Fair Value Adjustment of Warrants
Fair value of warrant shares
Other risks and uncertainties.
Other Risks And Uncertainties Policy Policy [Text Block]
Other Risks and Uncertainties
Defined Contribution Plan [Text Block]
401(K) Plan
Expected payments percentage to equal actual award received.
Expected Payments Percentage To Equal Actual Award Received
Expected payments percentage to equal actual award received
Schedule of Impact of Adoption of New Accounting Standard
Accounting Standards Update and Change in Accounting Principle [Table Text Block]
Derivative Liability, Fair Value, Gross Liability
Estimated fair value of derivative liability
Derivative Liability, Fair Value, Gross Liability, Total
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Options granted
Vesting of common stock warrant in return for services.
Vesting Of Common Stock Warrant In Return For Services
Vesting of common stock warrant in return for services
Sale of Stock [Domain]
Sale of Stock
Temporary Equity, Shares Issued
Temporary equity, shares issued
Shares Issued
Equity [Abstract]
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Options expired
Increase (Decrease) in Derivative Liabilities
Change in fair value of derivative liability
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Thereafter
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Plan Name [Domain]
Plan Name
Temporary Equity, by Class of Stock [Table]
Temporary Equity By Class Of Stock [Table]
Class of Stock [Line Items]
Class Of Stock [Line Items]
Temporary equity stock issued during period shares new issues.
Temporary Equity Stock Issued During Period Shares New Issues
Issuance of redeemable convertible preferred stock, net of $3,138 of issuance cost (in shares)
Continuous period where the Company ceases to develop or commercialize any product.
Continuous Period Where Company Ceases To Develop Or Commercialize Any Product
Continuous period where the Company ceases to develop or commercialize any product
Income Tax Authority [Axis]
Income Tax Authority
Depreciation
Depreciation expense
Depreciation, Total
Summary of Supplemental Information Related to Leases
Lessee, Operating Lease, Disclosure [Table Text Block]
Weighted-average remaining lease term (in years)
Lessee, Operating Lease, Term of Contract
Vesting of common stock warrants issued for services
Adjustments to additional paid in capital vesting of stock warrant issued for services.
Adjustments To Additional Paid In Capital Vesting Of Stock Warrant Issued For Services
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase in valuation allowance, deferred tax asset
Accounts Receivable, Allowance for Credit Loss, Writeoff
Write-offs relating to uncollectible accounts receivable
Issuance of common stock upon initial public offering, net of issuance cost
Stock Issued During Period, Value, New Issues
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date
Co-founder and Chief Scientific Advisor [Member]
Co Founder And Chief Scientific Advisor [Member]
David Schaffer, PhD,
Common stock warrants.
Common Stock Warrants [Text Block]
Common Stock Warrants
Number of marketable securities unrealized loss position more than one year
Number of marketable securities unrealized loss position more than one year.
Number of Marketable Securities Unrealized Loss Position More Than One Year
Non-refundable upfront payments received
Collaboration Arrangements Non Refundable Upfront Payment Received
Collaboration arrangements non-refundable upfront payment received.
Two thousand twenty equity incentive plan.
Two Thousand Twenty Equity Incentive Plan [Member]
2020 Equity Incentive Plan
Share-based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense, Total
Prepaid expenses and other current assets (includes $285 and $169 at December 31, 2021 and 2020, respectively, attributable to related parties)
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Options Activity
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Related Party Transactions [Abstract]
Share based compensation arrangement by share based payment award exercise price as percentage of fair market value minimum.
Share Based Compensation Arrangement By Share Based Payment Award Exercise Price As Percentage Of Fair Market Value Minimum
Exercise price as percentage of fair market value, minimum
Lessor, Operating Lease, Term of Contract
Lease initial term
Temporary Equity [Table Text Block]
Summary of Redeemable Convertible Preferred Stock
Number of Shares Underlying Outstanding Options, Shares exercisable, December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Employee Subscription Rate
Percentage of maximum contributions of employee's eligible compensation
Commitments and Contingencies Disclosure [Abstract]
Decrease in right-of-use assets due to reduction in operating lease liabilities upon modification
Decrease in right-of-use assets due to reduction in operating lease liabilities upon modification
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Assets
Total assets
Fair Value, Inputs, Level 2 [Member]
Level 2
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Issuance of common stock upon exercise of stock options (in shares)
Number of Shares Underlying Outstanding Options, exercised
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Accrued interest and penalties related to unrecognized tax benefits
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total
Statement [Line Items]
Statement [Line Items]
Total liabilities and stockholders' equity
Liabilities and Equity
Fair value of options.
Fair Value Of Options
Fair value of options
Balance Sheet Location [Domain]
Balance Sheet Location
Class of Warrant or Right [Axis]
Class of Warrant or Right
Revenue from External Customers by Geographic Areas [Table Text Block]
Schedule of Revenues by Geographic Region
Property, Plant and Equipment [Abstract]
Statement of Cash Flows [Abstract]
Accrued research and development.
Accrued Research And Development Policy Policy [Text Block]
Accrued Research and Development
Other-than-temporary impairment on investment in debt securities available-for-sale
Other-than-temporary Impairment Loss, Debt Securities, Available-for-sale, Recognized in Earnings
Tenant improvement allowance
Payments for Tenant Improvements
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Investment Income [Table]
Title of 12(b) Security
Title of 12(b) Security
Collaboration and License Revenue.
Collaboration And License Revenue [Member]
Collaboration and License Revenue
Total comprehensive loss
Total comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Schedule of collaboration and license revenue.
Schedule Of Collaboration And License Revenue Table [Text Block]
Summary of Collaboration and License Revenue
Share based compensation arrangement by share based payment award shares available for grant grants in period gross.
Share Based Compensation Arrangement By Share Based Payment Award Shares Available For Grant Grants In Period Gross
Number of Shares Available for Grant, Options granted
Fair Value, Inputs, Level 3 [Member]
Level 3
Minimum percentage of outstanding shares held by individual
Minimum Percentage Of Outstanding Shares Held By Individual
Minimum percentage of outstanding shares held by individual
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer
Collaborative arrangement total amount of award
CARES Act Relief description.
C A R E S Act Relief Description
CARES Act, relief description
Collaborative arrangement achieved milestones.
Collaborative Arrangement Achieved Milestones
Collaborative arrangement achieved milestones
Award Type [Domain]
Award Type
Gross unrealized loss on marketable securities
Stock issued during period value net unrealized gain (loss) on sale of marketable securities.
Stock Issued During Period Value Net Unrealized Gain (Loss) on Sale of Marketable Securities
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Investment Income, Interest
Interest income
Property, Plant and Equipment [Table Text Block]
Schedule of Property and Equipment, Net
Fair Value, Inputs, Level 1 [Member]
Level 1
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type
2025
Lessee, Operating Lease, Liability, to be Paid, Year Four
Temporary equity stock issued during period value conversion of convertible securities.
Temporary Equity Stock Issued During Period Value Conversion Of Convertible Securities
Conversion of redeemable convertible preferred stock into common stock
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Valuation allowance
Issuance of common stock upon exercise of stock options and warrants (in shares)
Stock Issued During Period Shares Stock Options And Warrants Exercised
Stock issued during period shares stock options and warrants exercised.
Nonoperating Income (Expense)
Total other income (expense)
Corporate Bonds
Corporate Debt Securities [Member]
Weighted-Average Exercise Price, Shares vested and expected to vest, December 31,2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Temporary Equity, Liquidation Preference
Temporary equity, liquidation preference
Liquidation Value
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Number of Shares Underlying Outstanding Options, granted
Number of stock options granted
Entity Current Reporting Status
Entity Current Reporting Status
Collaborative Arrangement Disclosure [Text Block]
Research and Collaboration Arrangements
Investment Type [Axis]
Purchase of marketable securities
Purchase of marketable securities
Payments to Acquire Marketable Securities
Payments to Acquire Marketable Securities, Total
Aggregate amount of transaction price allocated to remaining performance obligation
Aggregate amount of the transaction price remaining performance obligation
Remaining performance obligations
Entity Voluntary Filers
Entity Voluntary Filers
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Risk-free interest rate, minimum
Money Market Funds [Member]
Money Market Funds
Retirement Plan Name [Axis]
Retirement Plan Name
Collaborative arrangement additional research term.
Collaborative Arrangement Additional Research Term
Collaborative arrangement additional research term
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Lessee, Operating Lease, Option to Extend
Lease option to renew term description
Debt Securities, Available-for-sale [Table]
Series B financing.
Series B Financing [Member]
Series B Financing
Net Loss Per Share, Basic and Diluted
Earnings Per Share, Policy [Policy Text Block]
SWITZERLAND
Switzerland
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock Compensation Expense for Employees and Nonemployees by Function
Retirement Benefits [Abstract]
Funding Agreement Product
Funding agreement product.
Funding Agreement Product [Member]
Computer Equipment [Member]
Computer Equipment and Software
Research and Collaboration Arrangements.
Research And Collaboration Arrangements [Abstract]
Schedule of Weighted Average Number of Shares [Table Text Block]
Computation of Basic and Diluted Net Loss Per Share
Accumulated Other Comprehensive Loss
AOCI Attributable to Parent [Member]
Warrant vests over period.
Warrant Vests Over Period
Warrant vesting period
Share based compensation arrangement by share based payment award shares available for grant forfeitures in period.
Share Based Compensation Arrangement By Share Based Payment Award Shares Available For Grant Forfeitures In Period
Number of Shares Available for Grant, Options forfeited
Auditor Firm ID
Income Statement Location [Domain]
Income Statement Location
Summary of Changes in Fair Value of Level 3 Derivative Liability
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
UNITED STATES
United States
Tax credit carryforward expiration description.
Tax Credit Carryforward Expiration Description
Tax credit carryforward, expiration description
Receivables, Trade and Other Accounts Receivable, Allowance for Doubtful Accounts, Policy [Policy Text Block]
Accounts Receivable—Allowance for Doubtful Accounts
Class of Warrant or Right [Table]
Class Of Warrant Or Right [Table]
Auditor Name
Office Equipment [Member]
Office Equipment
ASC 842 Adjustments
Cumulative Effect, Period of Adoption, Adjustment
Sponsored Research Agreements.
Sponsored Research Agreements [Member]
SRAs
Non-refundable development milestone payments
Collaboration Arrangements Non Refundable Development Milestone Payments
Collaboration arrangements non-refundable development milestone payments.
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Weighted-Average Exercise Price, Shares exercisable, December 31,2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Increase (Decrease) in Accrued Liabilities
Accrued and other liabilities
Increase (Decrease) in Accrued Liabilities, Total
Fair value assumptions probability of change in control event percentage.
Fair Value Assumptions Probability Of Change In Control Event Percentage
Change in control event percentage
Minimum [Member]
Minimum
Weighted-Average Remaining Contractual Term (in years), Shares vested and expected to vest, December 31,2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Measurement Frequency [Domain]
Measurement Frequency
Stock Issued During Period, Value, Stock Options Exercised
Issuance of common stock upon exercise of stock options
Accounting Standards Update and Change in Accounting Principle [Table]
Deferred rent
Deferred Rent Credit
Amount obligated to pay upon closing first qualified financing at option.
Amount Obligated To Pay Upon Closing First Qualified Financing At Option
Amount obligated to pay upon closing first qualified financing at option of UC Regents
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrant shares exercisable
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
The Company
Document Annual Report
Document Annual Report
SRAs and Machine Learning SRA
Sponsored Research Agreements And Machine Learning Sponsored Research Agreements [Member]
Series A-1 redeemable convertible preferred stock.
Series A1 Redeemable Convertible Preferred Stock [Member]
Series A-1 Redeemable Convertible Preferred Stock
Deferred Tax Assets, Valuation Allowance
Less: valuation allowance
Deferred Tax Assets, Valuation Allowance, Total
Net Cash Provided by (Used in) Financing Activities [Abstract]
Cash flows from financing activities
Commitment and contingencies.
Commitment And Contingencies [Line Items]
Commitment And Contingencies [Line Items]
Entity Filer Category
Entity Filer Category
Income Tax, Policy [Policy Text Block]
Income Taxes
Collaborative arrangement transaction price adjustment.
Collaborative Arrangement Transaction Price Adjustment
Collaborative arrangement transaction price adjustment
Document Fiscal Year Focus
Document Fiscal Year Focus
Series C Redeemable Convertible Preferred Stock.
Series C Redeemable Convertible Preferred Stock [Member]
Series C Redeemable Convertible Preferred Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Number of Shares Underlying Outstanding Options, Shares vested and expected to vest, December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Construction in Progress [Member]
Construction in Progress
Operating lease liabilities
Deferred Tax Assets, Operating Lease Liabilities
Deferred tax assets, operating lease liabilities
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Issuance of common stock warrant to settle liability
Non cash Issuance Of Common Stock Warrant to settle liability
Non cash Issuance Of Common Stock Warrant to settle liability
Income Tax Disclosure [Text Block]
Income Taxes
Depreciation, Depletion and Amortization, Nonproduction
Depreciation and amortization
Depreciation, Depletion and Amortization, Nonproduction, Total
Deferred Revenue, by Arrangement, Disclosure [Table Text Block]
Summary of Deferred Revenue
Entity Ex Transition Period
Entity Ex Transition Period
Accounts payable to related parties
Accounts Payable, Related Parties, Current
Fair Value Disclosures [Abstract]
Amended uniQure agreement.
Amended Uni Qure Agreement [Member]
Amended uniQure Agreement
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, Net
Fair value assumptions change of control payment.
Fair Value Assumptions Change Of Control Payment
Change of control payment
F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc.
F Hoffmann La Roche Ltd And Hoffmann La Roche Inc [Member]
Roche
Maximum [Member]
Maximum
Entity Central Index Key
Entity Central Index Key
Payables and Accruals [Abstract]
Operating lease expense
Operating Lease, Expense
Annual rent
Temporary Equity [Line Items]
Temporary Equity [Line Items]
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Temporary Equity Disclosure [Abstract]
Entity Tax Identification Number
Entity Tax Identification Number
Equity Component [Domain]
Equity Component
Fair value assumptions probability of change in control discount rate.
Fair Value Assumptions Probability Of Change In Control Discount Rate
Change in control discount rate
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Summary of Available for Sale Securities
Debt Securities, Available-for-sale [Table Text Block]
Proceeds from Issuance of Private Placement
Proceeds from offering of securities in a private placement
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, Net
Related Party Costs
Payment to related party
Income Tax Authority [Domain]
Income Tax Authority
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized stock-based compensation, expected to be recognized over weighted-average period
Number of financial institutions where cash is held.
Number Of Financial Institutions Where Cash Is Held
Number of financial institutions cash is held
Other payable
Other Sundry Liabilities, Noncurrent
Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration
Net operating loss carryforward indefinitely
Actual award payment period upon first commercial sale of product.
Actual Award Payment Period Upon First Commercial Sale Of Product
Actual award payment period upon first commercial sale of product
Issuance of common stock warrant in connection with settlement
Issuance of common stock warrant
Adjustments to Additional Paid in Capital, Warrant Issued
Increase (Decrease) in Accounts Receivable
Accounts receivable
Change in accounting principle accounting standards update, adoption date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
License arrangements.
License Arrangements [Abstract]
Leasehold Improvements [Member]
Leasehold Improvements
Number of shares authorized and reserved for issuance
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Number of shares authorized and reserved for issuance
Concentration Risk, Percentage
Concentration risk, percentage
Statement [Table]
Statement [Table]
Entity File Number
Entity File Number
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase (Decrease) in Other Noncurrent Assets
Other assets
Retained Earnings [Member]
Accumulated Deficit
Shares Issued, Price Per Share
Stock sold and issued price per share
Accounting Standards Update [Domain]
Accounting Standards Update
Accounting Standards Update [Axis]
Accounting Standards Update
Revenue from Contract with Customer, Excluding Assessed Tax
Collaboration and license revenue
Revenue recognized
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Number of shares priced under public offering
Shares, Issued
Shares, Issued, Ending Balance
Shares, Issued, Beginning Balance
Weighted-average discount rate
Operating lease, discount rate
Lessee, Operating Lease, Discount Rate
Research and development expense related party.
Research And Development Expense Related Party
Research and development expense, related party
Liabilities, Current [Abstract]
Current liabilities
Share-based Payment Arrangement [Text Block]
Stock-based Compensation
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Present value of future minimum lease payments
Present value of future minimum lease payments
Operating lease liability
Lease liabilities
Common Stock [Member]
Common Stock
Property, Plant and Equipment, Gross
Total property and equipment
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Accrued Professional Fees, Current
Consulting and professional
Issuance of common stock through 2020 ESPP
Proceeds, Issuance of Shares, Share-based Payment Arrangement, Excluding Option Exercised
Entity Public Float
Entity Public Float
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period
Number of Shares Underlying Outstanding Options, expired
Cover [Abstract]
Asset Class [Axis]
Asset Class
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and development credit carryforward
Related Party Transaction [Domain]
Related Party Transaction
5980 Horton Street Building Lease
5980 Horton Street Building Lease
Building lease.
Redeemable Convertible Preferred Stock, ending balances (in shares)
Redeemable Convertible Preferred Stock, beginning balances (in shares)
Outstanding shares of redeemable convertible preferred stock
Temporary Equity, Shares Outstanding
Shares Outstanding
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Statement of Stockholders' Equity [Abstract]
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Concentration Risk [Table]
Concentration Risk [Table]
Number of Operating Segments
Number of operating segments
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Ending Balance
Beginning Balance
Share-based Payment Arrangement [Abstract]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Fair Value, Measurement with Unobservable Inputs Reconciliation, Liability, Transfers out of Level 3
Liabilities, Transfers out of Level 3
Short-term Marketable Securities
Short-term marketable securities.
Short-term Marketable Securities [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Nonemployee Consultants
Nonemployee.
Nonemployee [Member]
Nonemployee
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Number of warrants issued.
Number Of Warrants Issued
Number of warrants issued
Commitment and contingencies.
Commitment And Contingencies [Table]
Commitment And Contingencies [Table]
Other Accrued Liabilities, Current
Other accrued expenses
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan Disclosure [Line Items]
Document Transition Report
Document Transition Report
Operating lease right-of-use assets
Operating lease right-of-use assets
Deferred Tax Liabilities, Operating Lease Right-of-Use Assets
Deferred Tax Liabilities, operating lease right-of-use assets
Collaborative arrangements future sales based milestone payments percentage.
Collaborative Arrangements Future Sales Based Milestone Payments Percentage
Future sales-based milestone payments percentage
Customer B.
Customer B [Member]
Customer B
Consulting Services and Services as Board of Director
Consulting Services And Services As Board Of Director [Member]
Lessee, Operating Lease, Renewal Term
Lease renewal term
Derivative Instruments and Hedging Activities Disclosure [Text Block]
Derivative Liability
Non-refundable license fee payable upon execution every year after execution.
Non Refundable License Fee Payable Every Year After Execution
Non-refundable license fee payable upon execution every year thereafter until sales of a licensed product and payment of royalties
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Deferred revenue, net of current portion
Contract with Customer, Liability, Noncurrent
Common stock warrants.
Common Stock Warrants Policy Policy [Text Block]
Common Stock Warrants
Dividends, Common Stock
Common stock dividend
Dividends, Common Stock, Total
Total stock-based compensation expense
Share-based Payment Arrangement, Expense
Stock-based compensation expense
Maximum development milestone payments
Collaboration Arrangements Maximum Development Milestone Payments
Collaboration arrangements maximum development milestone payments.
Fair Value, Liabilities, Level 2 to Level 1 Transfers, Amount
Liabilities, Level 2 to Level 1 transfers
Redeemable convertible preferred stock.
Redeemable Convertible Preferred Stock Policy Policy [Text Block]
Redeemable Convertible Preferred Stock
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark
Statement of Financial Position [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Due to Related Parties
Amount due to related party
Due to Related Parties, Total
Deferred Tax Assets, Goodwill and Intangible Assets
Intangible asset basis
Lease Contractual Term [Axis]
Amortization of right-of-use assets
Operating Lease, Right-of-Use Asset, Amortization Expense
2026
Lessee, Operating Lease, Liability, to be Paid, Year Five
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Federal statutory income tax rate
Choroideremia Research Foundation.
Choroideremia Research Foundation [Member]
CRF
Stockholders' equity
Stockholders' Equity Attributable to Parent [Abstract]
Tax credit carryforward beginning expiration year.
Tax Credit Carryforward Beginning Expiration Year
Tax credit carryforward beginning expiration year
Temporary equity disclosure.
Temporary Equity Disclosure [Text Block]
Redeemable Convertible Preferred Stock
Lease Contractual Term [Domain]
Temporary equity stock issued during period shares conversion of convertible securities.
Temporary Equity Stock Issued During Period Shares Conversion Of Convertible Securities
Conversion of redeemable convertible preferred stock into common stock (in shares)
Compensation Related Costs, Policy [Policy Text Block]
Stock-Based Compensation
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Change in fair value included in other income (expense), net
Development milestones.
Development Milestones
Development milestones
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Options exercised
Weighted Average Number of Shares Issued, Basic
Weighted-average shares outstanding
Other Noncurrent Liabilities [Table Text Block]
Summary of Other Liabilities, Noncurrent
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities
2024
Lessee, Operating Lease, Liability, to be Paid, Year Three
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Common Stock, Capital Shares Reserved for Future Issuance
Common stock reserved
Number of shares reserved for issuance
Retirement Plan Name [Domain]
Retirement Plan Name
Measurement Frequency [Axis]
Measurement Frequency
Award Type [Axis]
Award Type
Entity Shell Company
Entity Shell Company
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-sale [Line Items]
Accrued and other liabilities.
Accrued And Other Liabilities [Text Block]
Accrued and Other Liabilities, Current and Noncurrent
Collaborative arrangement contribution upon development milestone.
Collaborative Arrangement Contribution Upon Development Milestone
Collaborative arrangement contribution upon development milestone
Liabilities and Stockholders' Equity
Liabilities and Equity [Abstract]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Issuance of common stock - 2020 ESPP
Stock Issued During Period, Value, Employee Stock Purchase Plan
Marketable securities
Marketable Securities
Marketable Securities, Total
Net Loss Per Share, Basic and Diluted
Earnings Per Share [Text Block]
Counterparty Name [Domain]
Counterparty Name
Annual royalty.
Annual Royalty
Annual royalty
Options to purchase ordinary shares.
Options To Purchase Ordinary Shares
Options to purchase ordinary shares
Amendment Flag
Amendment Flag
Schedule of Stock by Class [Table]
Schedule Of Stock By Class [Table]
Product and Service [Axis]
Product and Service
Nonoperating Income (Expense) [Abstract]
Other income (expense):
Conversion of Stock, Amount Converted
Conversion of redeemable convertible preferred stock into common stock
Other Nonoperating Income (Expense)
Other income (expense), net
Other Nonoperating Income (Expense), Total
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value
Fair value of options vested
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements
Title of Individual [Domain]
Title of Individual
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Permanent differences
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Two thousand twenty employee stock purchase plan.
Two Thousand Twenty Employee Stock Purchase Plan [Member]
2020 ESPP
Term of agreement.
Term Of Agreement
Agreement term
Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation of unvested options
Operating lease term extended expiration period.
Operating Lease Term Extended Expiration Period
Lease extended term period
Marketable securities
Marketable Securities, Current
Marketable Securities, Current, Total
Fair Value, Recurring [Member]
Fair Value on Recurring Basis
Fair Value, Assets, Level 1 to Level 2 Transfers, Amount
Assets, Level 1 to Level 2 transfers
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Other Assets, Noncurrent
Other assets
Other Assets, Noncurrent, Total
Employee Stock [Member]
Employee Stock Share Purchase Plan
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Customer
Customer.
Customer Member
Geographical [Domain]
Geographical
Customer [Domain]
Customer
Aggregate Intrinsic Value, Shares exercisable, December 31,2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Employee purchase price of common stock as percentage of fair market value
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent
Schedules of Concentration of Risk, by Risk Factor [Table Text Block]
Schedule of Concentration of Risk
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Additions for tax positions of prior years
Sale of Stock [Axis]
Sale of Stock
Fair Value Disclosures [Text Block]
Fair Value Measurements
Cumulative Effect, Period of Adoption [Domain]
Cumulative Effect, Period of Adoption
Issuance of common stock upon offerings, net of issuance costs
Proceeds from Issuance of Common Stock
Aggregate net proceeds, after deducting underwriting discounts and commissions and offering costs