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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
(Rule 13d-102)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
PURSUANT TO RULE 13d-2(b)
(Amendment No. 1) 1
4D Molecular Therapeutics, Inc.
(Name of Issuer)
Common Stock, $0.0001 par value
(Title of Class of Securities)
35104E100
(CUSIP Number)
December 31, 2021
(Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

[ ] Rule 13d-1(b)

[ ] Rule 13d-1(c)

[X] Rule 13d-1(d)    

__________
1 The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act.


CUSIP No. 35104E100

1.
NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (VOLUNTARY)

Pfizer Inc.      13-5315170
2.CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) [ ]
(b) [ ]
3.SEC USE ONLY
4.
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH		5.
SOLE VOTING POWER 0
6.
SHARED VOTING POWER 341,658 shares of Common Stock, $0.0001 par value per share (“Common Stock”) held directly by Pfizer Ventures (US) LLC, a wholly-owned subsidiary of Pfizer Inc.
7.SOLE DISPOSITIVE POWER 0
8.SHARED DISPOSITIVE POWER 341,658 shares of Common Stock held directly by Pfizer Ventures (US) LLC, a wholly-owned subsidiary of Pfizer Inc.
9.AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON 341,658*
10.
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
 
 [ ]
11.PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 1.06%**
12.TYPE OF REPORTING PERSON CO

*Represents shares held directly by Pfizer Ventures (US) LLC. Pfizer Inc. may be deemed to have beneficial ownership over such shares since Pfizer Ventures (US) LLC is a wholly-owned subsidiary of Pfizer Inc.
** Based on 32,138,814 shares of Common Stock outstanding as set forth in the Issuer’s Quarterly Report on Form 10-Q for the quarterly period ended on September 30, 2021, filed with the SEC on November 10, 2021.
Page 2 of 7

CUSIP No. 35104E100
1.
NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (VOLUNTARY)

Pfizer Ventures (US) LLC    82-5524518 
2.CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) [ ]
(b) [ ]
3.SEC USE ONLY
4.
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
NUMBER OF
SHARES
BENEFICIALLY
OWNED BY
EACH
REPORTING
PERSON
WITH		5.SOLE VOTING POWER -0-
6.SHARED VOTING POWER 341,658 Shares of Common Stock
7.SOLE DISPOSITIVE POWER -0-
8.SHARED DISPOSITIVE POWER 341,658 shares of Common Stock
9.AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON 341,658 shares of Common Stock held directly by Pfizer Ventures (US) LLC, a wholly-owned subsidiary of Pfizer Inc.
10.
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
 
 [ ]
11.PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 1.06%**
12.TYPE OF REPORTING PERSON OO


** Based on 32,138,814 shares of Common Stock outstanding as set forth in the Issuer’s Quarterly Report on Form 10-Q for the quarterly period ended on September 30, 2021, filed with the SEC on November 10, 2021.
Page 3 of 7

CUSIP No. 35104E100
SCHEDULE 13G


ITEM 1(a)
NAME OF ISSUER: 4D Molecular Therapeutics, Inc. (the “Issuer”).
ITEM 1(b)ADDRESS OF ISSUER’S PRINCIPAL EXECUTIVE OFFICES:
5858 Horton Street #455, Emeryville, California 94608
ITEM 2(a)NAME OF PERSON FILING:
Pfizer Inc. (“Pfizer”)
Pfizer Ventures (US) LLC (“PVUS”)

PVUS is a wholly-owned subsidiary of Pfizer. (See the Joint Filing Agreement between Pfizer and PVUS filed as Exhibit 99.1 hereto.)
ITEM 2(b)ADDRESS OF PRINCIPAL BUSINESS OFFICE:
Pfizer and PVUS: 235 East 42nd Street, New York, NY 10017
ITEM 2(c)CITIZENSHIP:
Pfizer and PVUS: Delaware
ITEM 2(d)TITLE OF CLASS OF SECURITIES:
Common Stock, $0.0001 par value
ITEM 2(e)CUSIP NUMBER: 35104E100
ITEM 3STATEMENTS FILED PURSUANT TO RULES 13D-1(B) OR 13D-2(B) OR (C):
Not applicable.

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CUSIP No. 35104E100

ITEM 4OWNERSHIP:
The information requested in this item is incorporated herein by reference to rows 5 through 11 of the respective cover pages of Pfizer and PVUS to this Schedule 13G.
ITEM 5OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS:
| X |
ITEM 6OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:
Not applicable.
ITEM 7IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT COMPANY:
Not applicable.

ITEM 8IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP:
Not applicable.
ITEM 9NOTICE OF DISSOLUTION OF GROUP:
Not applicable.
ITEM 10CERTIFICATION:
Not applicable.

Page 5 of 7

CUSIP No. 35104E100

EXHIBIT INDEX
Exhibit Description

99.1Joint Filing Agreement, dated as of February 16, 2021, by and between Pfizer and PVUS (Incorporated by reference to Exhibit 99.1 to the Schedule 13G filed by and among the Reporting Persons on February 16, 2021).


Page 6 of 7

CUSIP No. 35104E100

SIGNATURE

After reasonable inquiry and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.

Dated: February 11, 2022

PFIZER INC.
By:/s/ Susan Grant
Name:Susan Grant
Title:Assistant Secretary
PFIZER VENTURES (US) LLC
By:/s/ Susan Grant
Name:Susan Grant
Title:Secretary

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